Statistical and Biological Physics

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Many fundamental cellular processes are spatially regulated by self-organized protein patterns, which are often based on nucleotide-binding proteins that switch their nucleotide state upon interaction with a second, activating protein. For reliable function, these protein patterns must be robust against parameter changes, although the basis for such robustness is generally elusive. Here, we take a combined theoretical and experimental approach to the E. coli Min system, a paradigmatic system for protein self-organization. more

Molecular motors of the kinesin-8 family are important regulators of the length of microtubules, filamentous polymers which play vital roles in chromosome segregation and molecular transport. In our work we have addressed the question how length regulation functions in compartments of finite size, i.e., when the availability of protein is limited. more